Winning the Emirates Airline Twenty20 competition at Dubai's Sevens Complex was one step too far for Lancashire, who were comprehensively beaten in the final by Sussex under lights.
The Sharks gained revenge for last August's Friends Life t20 quarter-final defeat at Hove by defending their commanding 162-6 from 20 overs on a slow pitch.
Luke Wells hit 45, Andrew Hodd 42 and Mike Yardy 21 off nine balls at the death, helping to take 30 runs off the last two overs.
Oliver Newby was the pick of the Lancashire bowlers with 3-26 from four overs.
The Lightning, looking tired after three games on the reel including two in very hot conditions, then lost early wickets in their reply, with leg-spinner Will Beer taking 4-26 from 3.5 overs. Nobody else topped Karl Brown's 39 off 24 balls as they slipped to 105 all out inside 16 overs.
Although Glen Chapple sat out the three games, he is fit and will lead the side in the four-day match against MCC at Abu Dhabi next week.
Photo & Article (c) Lancashire CCC